Cross-linked hyaluronic acid is widely used in cosmetic injections for wrinkle improvement, tear trough filling, lip augmentation, and nose and chin contouring. Highly cross-linked products offer strong support and long-lasting results, while low-cross-linked products are commonly used in dermal injections and skin repair, helping to hydrate and combat aging.

In medicine, cross-linked hyaluronic acid is often used for intra-articular injections to relieve osteoarthritis pain and improve mobility. It also serves as a viscoelastic material to protect tissue and maintain eye space during ophthalmic surgeries such as cataract and corneal transplants.

It provides a moist environment to promote wound healing and tissue repair. It can also serve as a sustained-release drug carrier for localized delivery and is an important scaffold material for soft tissue repair and regeneration.

While most cosmetics use uncross-linked hyaluronic acid, cross-linked hyaluronic acid, due to its long-lasting moisturizing properties and excellent film-forming properties, has gradually been adopted in high-end skincare products for long-lasting hydration and firming.